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Peptide record

TPDB47717

ACE inhibitor Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47717
ACE inhibitor
Antihypertensive
Cardiometabolic peptides
AHTPDB AHTpin Peptipedia
standard
No
A 3-aa standard natural antihypertensive peptide sequence curated from AHTPDB, AHTpin, and Peptipedia, with an available 3D structural model.
Sequence
VVW
Physicochemical Analysis
C21H30N4O4
ARNDCEQGHILKMFPSTY
V
402.49
6.02
0
0
3
-0
-1.71
2.500
193.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
1366.48
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
3
C21H30N4O4
402.49
6.02
-0
-1.71
2.500
402.4861
402.2260
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
76.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Xie J., Chen X., Wu J., Zhang Y., Zhou Y., Zhang L., Tang Y. J., Wei D.
Antihypertensive effects, molecular docking study, and isothermal titration calorimetry assay of angiotensin I-converting enzyme inhibitory peptides from Chlorella vulgaris. J. Agric. Food Chem., 66, 1359-1368, 2018
2018
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C21H30N4O4/c1-11(2)17(22)19(26)25-18(12(3)4)20(27)24-16(21(28)29)9-13-10-23-15-8-6-5-7-14(13)15/h5-8,10-12,16-18,23H,9,22H2,1-4H3,(H,24,27)(H,25,26)(H,28,29)/t16-,17-,18-/m0/s1 InChIKey=WHNSHJJNWNSTSU-BZSNNMDCSA-N
Additional Detail Fields 1 fields
3