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Peptide record

TPDB47705

ACE inhibitor (fr.198-202 of bovine alphas2-casein) ACE inhibitors Antihypertensive Neuropeptide standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47705
ACE inhibitor (fr.198-202 of bovine alphas2-casein)
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
TKVIP
Physicochemical Analysis
C26H48N6O7
ARNDCEQGHLMFSWY
IKPTV
556.70
10.10
1
0
2
+1
1.34
0.500
136.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C26H48N6O7
556.70
10.10
+1
1.34
0.500
556.6934
556.3573
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
400.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79, 1316-1321, 1996
1996
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C26H48N6O7/c1-6-15(4)21(25(37)32-13-9-11-18(32)26(38)39)31-24(36)20(14(2)3)30-22(34)17(10-7-8-12-27)29-23(35)19(28)16(5)33/h14-21,33H,6-13,27-28H2,1-5H3,(H,29,35)(H,30,34)(H,31,36)(H,38,39)/t15-,16+,17-,18-,19-,20-,21-/m0/s1 InChIKey=NOVJRRNIFQGPCB-TVWVXWENSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
400.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Maeno M., Yamamoto N., Takano T.
Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci., 79, 1316-1321, 1996
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C26H48N6O7/c1-6-15(4)21(25(37)32-13-9-11-18(32)26(38)39)31-24(36)20(14(2)3)30-22(34)17(10-7-8-12-27)29-23(35)19(28)16(5)33/h14-21,33H,6-13,27-28H2,1-5H3,(H,29,35)(H,30,34)(H,31,36)(H,38,39)/t15-,16+,17-,18-,19-,20-,21-/m0/s1 InChIKey=NOVJRRNIFQGPCB-TVWVXWENSA-N
Additional Detail Fields 1 fields
5