TPDB

3D PDB MODEL

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TPDB ID TPDB47704

Peptide_Name

ACE inhibitor from sake lees

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

IYPRY

FASTA

>TPDB47704|ACE inhibitors;Antihypertensive|length=5
IYPRY

Formula C35H50N8O8

Absent Amino Acids ANDCEQGHLKMFSTWV

Common Amino Acids Y

Mass 710.83

PI 9.63

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -0.93

Hydrophobicity -0.840

Aliphatic Index 78.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 419.23

Polar Residues 2

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

5

Formula

C35H50N8O8

Mass

710.83

PI

9.63

Net Charge

+1

Boman Index

-0.93

Hydrophobicity

-0.840

Chemical_Mass

710.8183

Monoisotopic_Mass

710.3740

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 4.10 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C35H50N8O8/c1-3-20(2)29(36)32(48)41-26(18-21-8-12-23(44)13-9-21)33(49)43-17-5-7-28(43)31(47)40-25(6-4-16-39-35(37)38)30(46)42-27(34(50)51)19-22-10-14-24(45)15-11-22/h8-15,20,25-29,44-45H,3-7,16-19,36H2,1-2H3,(H,40,47)(H,41,48)(H,42,46)(H,50,51)(H4,37,38,39)/t20-,25-,26-,27-,28-,29-/m0/s1 InChIKey=MHTGCGBUKAKZJN-KOQQHMENSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 4.10 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C35H50N8O8/c1-3-20(2)29(36)32(48)41-26(18-21-8-12-23(44)13-9-21)33(49)43-17-5-7-28(43)31(47)40-25(6-4-16-39-35(37)38)30(46)42-27(34(50)51)19-22-10-14-24(45)15-11-22/h8-15,20,25-29,44-45H,3-7,16-19,36H2,1-2H3,(H,40,47)(H,41,48)(H,42,46)(H,50,51)(H4,37,38,39)/t20-,25-,26-,27-,28-,29-/m0/s1 InChIKey=MHTGCGBUKAKZJN-KOQQHMENSA-N

Number_of_Residues

5