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Peptide record

TPDB47694

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47694
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LNP
Physicochemical Analysis
C15H26N4O5
ARDCEQGHIKMFSTWYV
NLP
342.40
6.02
0
0
1
-0
0.31
-0.433
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C15H26N4O5
342.40
6.02
-0
0.31
-0.433
342.3897
342.1897
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
43.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H.
Structure and activity of angiotensin-converting enzyme inhibitors in alpha-zein hydrolysate. Agric. Biol. Chem., 55(5), 1313-1318 (1991)
1991
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C15H26N4O5/c1-8(2)6-9(16)13(21)18-10(7-12(17)20)14(22)19-5-3-4-11(19)15(23)24/h8-11H,3-7,16H2,1-2H3,(H2,17,20)(H,18,21)(H,23,24)/t9-,10-,11-/m0/s1 InChIKey=WGNOPSQMIQERPK-DCAQKATOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111
Evidence 2 Activity

Activity

IC50
Antihypertensive
43.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H.
Structure and activity of angiotensin-converting enzyme inhibitors in alpha-zein hydrolysate. Agric. Biol. Chem., 55(5), 1313-1318 (1991)
1991
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C15H26N4O5/c1-8(2)6-9(16)13(21)18-10(7-12(17)20)14(22)19-5-3-4-11(19)15(23)24/h8-11H,3-7,16H2,1-2H3,(H2,17,20)(H,18,21)(H,23,24)/t9-,10-,11-/m0/s1 InChIKey=WGNOPSQMIQERPK-DCAQKATOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111
Additional Detail Fields 1 fields
3