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Peptide record

TPDB47687

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47687
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
ITF
Physicochemical Analysis
C19H29N3O5
ARNDCEQGHLKMPSWYV
IFT
379.46
6.02
0
0
2
-0
-1.30
2.200
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C19H29N3O5
379.46
6.02
-0
-1.30
2.200
379.4495
379.2100
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
48.98 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Li C.-H., Matsui T., Matsumoto K., Yamasaki R., Kawasaki T.
Latent production of Angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Peptide Sci., 8, 267-274, 2002
2002
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)[C@H](O)C)[C@H](CC)C InChI=1S/C19H29N3O5/c1-4-11(2)15(20)17(24)22-16(12(3)23)18(25)21-14(19(26)27)10-13-8-6-5-7-9-13/h5-9,11-12,14-16,23H,4,10,20H2,1-3H3,(H,21,25)(H,22,24)(H,26,27)/t11-,12+,14-,15-,16-/m0/s1 InChIKey: WXLYNEHOGRYNFU-URLPEUOOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
48.98 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Li C.-H., Matsui T., Matsumoto K., Yamasaki R., Kawasaki T.
Latent production of Angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Peptide Sci., 8, 267-274, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)[C@H](O)C)[C@H](CC)C InChI=1S/C19H29N3O5/c1-4-11(2)15(20)17(24)22-16(12(3)23)18(25)21-14(19(26)27)10-13-8-6-5-7-9-13/h5-9,11-12,14-16,23H,4,10,20H2,1-3H3,(H,21,25)(H,22,24)(H,26,27)/t11-,12+,14-,15-,16-/m0/s1 InChIKey: WXLYNEHOGRYNFU-URLPEUOOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3