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Peptide record

TPDB47686

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47686
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LGI
Physicochemical Analysis
C14H27N3O4
ARNDCEQHKMFPSTWYV
GIL
301.39
6.02
0
0
2
-0
-0.86
2.633
260.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C14H27N3O4
301.39
6.02
-0
-0.86
2.633
301.3808
301.1995
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
28.84 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Li C.-H., Matsui T., Matsumoto K., Yamasaki R., Kawasaki T.
Latent production of Angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Peptide Sci., 8, 267-274, 2002
2002
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)[C@H](CC)C)CC(C)C InChI=1S/C14H27N3O4/c1-5-9(4)12(14(20)21)17-11(18)7-16-13(19)10(15)6-8(2)3/h8-10,12H,5-7,15H2,1-4H3,(H,16,19)(H,17,18)(H,20,21)/t9-,10-,12-/m0/s1 InChIKey: CCQLQKZTXZBXTN-NHCYSSNCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
28.84 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Li C.-H., Matsui T., Matsumoto K., Yamasaki R., Kawasaki T.
Latent production of Angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Peptide Sci., 8, 267-274, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)N[C@H](C(=O)O)[C@H](CC)C)CC(C)C InChI=1S/C14H27N3O4/c1-5-9(4)12(14(20)21)17-11(18)7-16-13(19)10(15)6-8(2)3/h8-10,12H,5-7,15H2,1-4H3,(H,16,19)(H,17,18)(H,20,21)/t9-,10-,12-/m0/s1 InChIKey: CCQLQKZTXZBXTN-NHCYSSNCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3