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Peptide record

TPDB47685

ACE inhibitor from buckwheat ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47685
ACE inhibitor from buckwheat
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PSY
Physicochemical Analysis
C17H23N3O6
ARNDCEQGHILKMFTWV
PSY
365.39
5.94
0
0
1
-0
-0.36
-1.233
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
407.79
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C17H23N3O6
365.39
5.94
-0
-0.36
-1.233
365.3801
365.1581
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
16.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Li C.-H., Matsui T., Matsumoto K., Yamasaki R., Kawasaki T.
Latent production of Angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Peptide Sci., 8, 267-274, 2002
2002
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C17H23N3O6/c21-9-14(20-15(23)12-2-1-7-18-12)16(24)19-13(17(25)26)8-10-3-5-11(22)6-4-10/h3-6,12-14,18,21-22H,1-2,7-9H2,(H,19,24)(H,20,23)(H,25,26)/t12-,13-,14-/m0/s1 InChIKey=UGDMQJSXSSZUKL-IHRRRGAJSA-N Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7) according to the BIOPEP-UWM Virtual database (ID 68)
Evidence 2 Activity

Activity

IC50
Antihypertensive
16.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Li C.-H., Matsui T., Matsumoto K., Yamasaki R., Kawasaki T.
Latent production of Angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Peptide Sci., 8, 267-274, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C17H23N3O6/c21-9-14(20-15(23)12-2-1-7-18-12)16(24)19-13(17(25)26)8-10-3-5-11(22)6-4-10/h3-6,12-14,18,21-22H,1-2,7-9H2,(H,19,24)(H,20,23)(H,25,26)/t12-,13-,14-/m0/s1 InChIKey=UGDMQJSXSSZUKL-IHRRRGAJSA-N Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7) according to the BIOPEP-UWM Virtual database (ID 68)
Additional Detail Fields 1 fields
3