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Peptide record

TPDB47683

ACE inhibitor Phenylalanine-asparagine-Phenylalanine ACE inhibitors Antihypertensive Selfassembly standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47683
ACE inhibitor Phenylalanine-asparagine-Phenylalanine
ACE inhibitors Antihypertensive Selfassembly
Cardiometabolic peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB SAPdb
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Selfassembly) peptide sequence curated from Peptipedia, AHTPDB, and SAPdb, with an available 3D structural model.
Sequence
FNF
Physicochemical Analysis
C22H26N4O5
ARDCEQGHILKMPSTWYV
F
426.47
6.02
0
0
2
-0
-1.84
0.700
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C22H26N4O5
426.47
6.02
-0
-1.84
0.700
426.4646
426.1897
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

29565077
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanotube
Selfassembly; Nanostructure=Nanotube
Selfassembly
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
6.92 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Matsui T., Yukiyoshi A., Doi S., Sugimoto H., Yamada H., Matsumoto K.
Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J. Nutr. Biochem., 13 (2), 80-86, 2002
2002
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C22H26N4O5/c23-16(11-14-7-3-1-4-8-14)20(28)25-17(13-19(24)27)21(29)26-18(22(30)31)12-15-9-5-2-6-10-15/h1-10,16-18H,11-13,23H2,(H2,24,27)(H,25,28)(H,26,29)(H,30,31)/t16-,17-,18-/m0/s1 InChIKey: AWAYOWOUGVZXOB-BZSNNMDCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
6.92 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Matsui T., Yukiyoshi A., Doi S., Sugimoto H., Yamada H., Matsumoto K.
Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J. Nutr. Biochem., 13 (2), 80-86, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C22H26N4O5/c23-16(11-14-7-3-1-4-8-14)20(28)25-17(13-19(24)27)21(29)26-18(22(30)31)12-15-9-5-2-6-10-15/h1-10,16-18H,11-13,23H2,(H2,24,27)(H,25,28)(H,26,29)(H,30,31)/t16-,17-,18-/m0/s1 InChIKey: AWAYOWOUGVZXOB-BZSNNMDCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanotube
Nanotube

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
29565077
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 5 fields
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
3
29565077
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly