TPDB

3D PDB MODEL

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TPDB ID TPDB47679

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia and AHTPDB, with an available 3D structural model.

Sequence

IMY

FASTA

>TPDB47679|ACE inhibitors;Antihypertensive|length=3
IMY

Formula C20H31N3O5S1

Absent Amino Acids ARNDCEQGHLKFPSTWV

Common Amino Acids IMY

Mass 425.54

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.48

Hydrophobicity 1.700

Aliphatic Index 130.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 350.14

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

1

M

0

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

3

Formula

C20H31N3O5S1

Mass

425.54

PI

5.94

Net Charge

-0

Boman Index

-1.48

Hydrophobicity

1.700

Chemical_Mass

425.5421

Monoisotopic_Mass

425.1977

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1.82 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Matsui T., Yukiyoshi A., Doi S., Sugimoto H., Yamada H., Matsumoto K.

Title

Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J. Nutr. Biochem., 13, 80-86, 2002

Year 2002

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CCSC)[C@H](CC)C InChI=1S/C20H31N3O5S/c1-4-12(2)17(21)19(26)22-15(9-10-29-3)18(25)23-16(20(27)28)11-13-5-7-14(24)8-6-13/h5-8,12,15-17,24H,4,9-11,21H2,1-3H3,(H,22,26)(H,23,25)(H,27,28)/t12-,15-,16-,17-/m0/s1 InChIKey: UOPBQSJRBONRON-STECZYCISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 1.82 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Matsui T., Yukiyoshi A., Doi S., Sugimoto H., Yamada H., Matsumoto K.

Title

Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J. Nutr. Biochem., 13, 80-86, 2002

Year 2002

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CCSC)[C@H](CC)C InChI=1S/C20H31N3O5S/c1-4-12(2)17(21)19(26)22-15(9-10-29-3)18(25)23-16(20(27)28)11-13-5-7-14(24)8-6-13/h5-8,12,15-17,24H,4,9-11,21H2,1-3H3,(H,22,26)(H,23,25)(H,27,28)/t12-,15-,16-,17-/m0/s1 InChIKey: UOPBQSJRBONRON-STECZYCISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

3