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Peptide record

TPDB47678

ACE inhibitor from as2-CN ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47678
ACE inhibitor from as2-CN
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
TVY
Physicochemical Analysis
C18H27N3O6
ARNDCEQGHILKMFPSW
TYV
381.43
5.94
0
0
2
-0
-0.73
0.733
96.67
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
390.64
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
3
C18H27N3O6
381.43
5.94
-0
-0.73
0.733
381.4224
381.1893
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
15.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Tauzin J., Miclo L., Gaillard J.-L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein. FEBS Lett., 531, 369-374
2002
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O InChI=1S/C18H27N3O6/c1-9(2)15(21-16(24)14(19)10(3)22)17(25)20-13(18(26)27)8-11-4-6-12(23)7-5-11/h4-7,9-10,13-15,22-23H,8,19H2,1-3H3,(H,20,25)(H,21,24)(H,26,27)/t10-,13+,14+,15+/m1/s1 InChIKey: BPGDJSUFQKWUBK-KJEVXHAQSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
15.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Tauzin J., Miclo L., Gaillard J.-L.
Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein. FEBS Lett., 531, 369-374
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP database of bioactive peptides SMILES: N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O InChI=1S/C18H27N3O6/c1-9(2)15(21-16(24)14(19)10(3)22)17(25)20-13(18(26)27)8-11-4-6-12(23)7-5-11/h4-7,9-10,13-15,22-23H,8,19H2,1-3H3,(H,20,25)(H,21,24)(H,26,27)/t10-,13+,14+,15+/m1/s1 InChIKey: BPGDJSUFQKWUBK-KJEVXHAQSA-N
Additional Detail Fields 1 fields
3