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Peptide record

TPDB47674

ACE inhibitor from b-CN (179-181) ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47674
ACE inhibitor from b-CN (179-181)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PYP
Physicochemical Analysis
C19H25N3O5
ARNDCEQGHILKMFSTWV
P
375.42
5.94
0
0
1
-0
-0.04
-1.500
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
396.88
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C19H25N3O5
375.42
5.94
-0
-0.04
-1.500
375.4179
375.1788
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
220.00 µM
ACE inhibitor
ah

Source & Reference

NA
Meisel H.
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality ed Schwenke K.D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75
1993
book

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1ccc(O)cc1)(NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C19H25N3O5/c23-13-7-5-12(6-8-13)11-15(21-17(24)14-3-1-9-20-14)18(25)22-10-2-4-16(22)19(26)27/h5-8,14-16,20,23H,1-4,9-11H2,(H,21,24)(H,26,27)/t14-,15-,16-/m0/s1 InChIKey=IALSFJSONJZBKB-JYJNAYRXSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
220.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H.
Casokinins as bioactive peptides in the primary strucure of casein. In: Food proteins, structure and functionality ed Schwenke K.D., Mothes R., VCh, Weinheim - New York - Basel - Cambridge - Tokyo, pp 67-75
1993
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1ccc(O)cc1)(NC(=O)[C@]1([H])CCCN1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C19H25N3O5/c23-13-7-5-12(6-8-13)11-15(21-17(24)14-3-1-9-20-14)18(25)22-10-2-4-16(22)19(26)27/h5-8,14-16,20,23H,1-4,9-11H2,(H,21,24)(H,26,27)/t14-,15-,16-/m0/s1 InChIKey=IALSFJSONJZBKB-JYJNAYRXSA-N
Additional Detail Fields 1 fields
3