TPDB

3D PDB MODEL

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TPDB ID TPDB47672

Peptide_Name

ACE inhibitor (from bovine alphas1-CN)

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

FGK

FASTA

>TPDB47672|ACE inhibitors;Antihypertensive|length=3
FGK

Formula C17H26N4O4

Absent Amino Acids ARNDCEQHILMPSTWYV

Common Amino Acids GKF

Mass 350.42

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +1

Boman Index -0.13

Hydrophobicity -0.500

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

1

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

3

Formula

C17H26N4O4

Mass

350.42

PI

10.10

Net Charge

+1

Boman Index

-0.13

Hydrophobicity

-0.500

Chemical_Mass

350.4117

Monoisotopic_Mass

350.1948

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 160.00 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.

Title

Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586, 1987

Year 1987

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C17H26N4O4/c18-9-5-4-8-14(17(24)25)21-15(22)11-20-16(23)13(19)10-12-6-2-1-3-7-12/h1-3,6-7,13-14H,4-5,8-11,18-19H2,(H,20,23)(H,21,22)(H,24,25)/t13-,14-/m0/s1 InChIKey=HBGFEEQFVBWYJQ-KBPBESRZSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 160.00 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.

Title

Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586, 1987

Year 1987

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C17H26N4O4/c18-9-5-4-8-14(17(24)25)21-15(22)11-20-16(23)13(19)10-12-6-2-1-3-7-12/h1-3,6-7,13-14H,4-5,8-11,18-19H2,(H,20,23)(H,21,22)(H,24,25)/t13-,14-/m0/s1 InChIKey=HBGFEEQFVBWYJQ-KBPBESRZSA-N

Number_of_Residues

3