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Peptide record

TPDB47671

ACE inhibitor from alphas1-CN ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47671
ACE inhibitor from alphas1-CN
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PLW
Physicochemical Analysis
C22H30N4O4
ARNDCEQGHIKMFSTYV
LPW
414.50
6.02
0
0
2
-0
-1.96
0.433
130.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
1326.89
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C22H30N4O4
414.50
6.02
-0
-1.96
0.433
414.4968
414.2260
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
36.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Angiotensin-I converting enzyme inhibitory activity of the C-terminal hexapeptide of a-casein. Agric.Biol.Chem., 51, 2557-2561(1987)
1987
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C22H30N4O4/c1-13(2)10-18(25-20(27)17-8-5-9-23-17)21(28)26-19(22(29)30)11-14-12-24-16-7-4-3-6-15(14)16/h3-4,6-7,12-13,17-19,23-24H,5,8-11H2,1-2H3,(H,25,27)(H,26,28)(H,29,30)/t17-,18-,19-/m0/s1 InChIKey=SRBFGSGDNNQABI-FHWLQOOXSA-N IC50(EC50)=22 from: Meisel H., Walsh D. J., Murray B., FitzGerald R. J.(2006). ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315. Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7) according to the BIOPEP-UWM Virtual database (ID 56)
Evidence 2 Activity

Activity

IC50
Antihypertensive
36.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Angiotensin-I converting enzyme inhibitory activity of the C-terminal hexapeptide of a-casein. Agric.Biol.Chem., 51, 2557-2561(1987)
1987
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C22H30N4O4/c1-13(2)10-18(25-20(27)17-8-5-9-23-17)21(28)26-19(22(29)30)11-14-12-24-16-7-4-3-6-15(14)16/h3-4,6-7,12-13,17-19,23-24H,5,8-11H2,1-2H3,(H,25,27)(H,26,28)(H,29,30)/t17-,18-,19-/m0/s1 InChIKey=SRBFGSGDNNQABI-FHWLQOOXSA-N IC50(EC50)=22 from: Meisel H., Walsh D. J., Murray B., FitzGerald R. J.(2006). ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315. Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB ID: 6LU7) according to the BIOPEP-UWM Virtual database (ID 56)
Additional Detail Fields 1 fields
3