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Peptide record

TPDB47670

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47670
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
FAP
Physicochemical Analysis
C17H23N3O4
RNDCEQGHILKMSTWYV
AFP
333.39
6.02
0
0
2
-0
-0.85
1.000
33.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C17H23N3O4
333.39
6.02
-0
-0.85
1.000
333.3813
333.1683
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3.80 µM
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586
1987
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C17H23N3O4/c1-11(16(22)20-9-5-8-14(20)17(23)24)19-15(21)13(18)10-12-6-3-2-4-7-12/h2-4,6-7,11,13-14H,5,8-10,18H2,1H3,(H,19,21)(H,23,24)/t11-,13-,14-/m0/s1 InChIKey=QMMRHASQEVCJGR-UBHSHLNASA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
3.80 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Mitachi H., Tanaka H., Tomizuka N., Suzuki H.
Studies on the active site and antihypertensive activity of angiotensin I-converting enzyme inhibitors derived from casein. Agric. Biol. Chem., 51, 1581-1586
1987
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C17H23N3O4/c1-11(16(22)20-9-5-8-14(20)17(23)24)19-15(21)13(18)10-12-6-3-2-4-7-12/h2-4,6-7,11,13-14H,5,8-10,18H2,1H3,(H,19,21)(H,23,24)/t11-,13-,14-/m0/s1 InChIKey=QMMRHASQEVCJGR-UBHSHLNASA-N
Additional Detail Fields 1 fields
3