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Peptide record

TPDB47667

ACE inhibitor Renin inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47667
ACE inhibitor Renin inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
PRY
Physicochemical Analysis
C20H30N6O5
ANDCEQGHILKMFSTWV
RPY
434.50
9.88
1
0
1
+1
0.32
-2.467
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
342.93
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C20H30N6O5
434.50
9.88
+1
0.32
-2.467
434.4882
434.2271
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58(10), 1767-1771 (1994)
1994
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C20H30N6O5/c21-20(22)24-10-2-4-15(25-17(28)14-3-1-9-23-14)18(29)26-16(19(30)31)11-12-5-7-13(27)8-6-12/h5-8,14-16,23,27H,1-4,9-11H2,(H,25,28)(H,26,29)(H,30,31)(H4,21,22,24)/t14-,15-,16-/m0/s1 InChIKey=OYEUSRAZOGIDBY-JYJNAYRXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the bRENDA database the DFBP database Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58(10), 1767-1771 (1994)
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C20H30N6O5/c21-20(22)24-10-2-4-15(25-17(28)14-3-1-9-23-14)18(29)26-16(19(30)31)11-12-5-7-13(27)8-6-12/h5-8,14-16,23,27H,1-4,9-11H2,(H,25,28)(H,26,29)(H,30,31)(H4,21,22,24)/t14-,15-,16-/m0/s1 InChIKey=OYEUSRAZOGIDBY-JYJNAYRXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the bRENDA database the DFBP database Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID: A01.007)
renin inhibitor
ren

Source & Reference

AHTPDB
Fu Y., Alashi A. M., Young J. F., Therkildsen M., Aluko R. E.
Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin. Int. J. Biol. Macromol., 101, 207-213, 2017
2017
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C20H30N6O5/c21-20(22)24-10-2-4-15(25-17(28)14-3-1-9-23-14)18(29)26-16(19(30)31)11-12-5-7-13(27)8-6-12/h5-8,14-16,23,27H,1-4,9-11H2,(H,25,28)(H,26,29)(H,30,31)(H4,21,22,24)/t14-,15-,16-/m0/s1 InChIKey=OYEUSRAZOGIDBY-JYJNAYRXSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 3536) the BRENDA database the DFBP database the EROP-Moscow database Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006)
Additional Detail Fields 1 fields
3