TPDB

3D PDB MODEL

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TPDB ID TPDB47663

Peptide_Name

ACE inhibitor from sake lees

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VWY

FASTA

>TPDB47663|ACE inhibitors;Antihypertensive|length=3
VWY

Formula C25H30N4O5

Absent Amino Acids ARNDCEQGHILKMFPST

Common Amino Acids WYV

Mass 466.54

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.72

Hydrophobicity 0.667

Aliphatic Index 96.67

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 1498.27

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1

Length

3

Formula

C25H30N4O5

Mass

466.54

PI

5.94

Net Charge

-0

Boman Index

-2.72

Hydrophobicity

0.667

Chemical_Mass

466.5283

Monoisotopic_Mass

466.2209

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 9.40 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1ccc(O)cc1)(NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@]([H])(N)C(C)C)C(O)=O InChI=1S/C25H30N4O5/c1-14(2)22(26)24(32)28-20(12-16-13-27-19-6-4-3-5-18(16)19)23(31)29-21(25(33)34)11-15-7-9-17(30)10-8-15/h3-10,13-14,20-22,27,30H,11-12,26H2,1-2H3,(H,28,32)(H,29,31)(H,33,34)/t20-,21-,22-/m0/s1 InChIKey=VBTFUDNTMCHPII-FKBYEOEOSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 9.40 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Saito Y., Wanezaki K., Kawato A., Imayasu S.

Title

Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci.Biotech.Biochem.58(10),1767-1771(1994)

Year 1994

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1ccc(O)cc1)(NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@]([H])(N)C(C)C)C(O)=O InChI=1S/C25H30N4O5/c1-14(2)22(26)24(32)28-20(12-16-13-27-19-6-4-3-5-18(16)19)23(31)29-21(25(33)34)11-15-7-9-17(30)10-8-15/h3-10,13-14,20-22,27,30H,11-12,26H2,1-2H3,(H,28,32)(H,29,31)(H,33,34)/t20-,21-,22-/m0/s1 InChIKey=VBTFUDNTMCHPII-FKBYEOEOSA-N

Number_of_Residues

3