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Peptide record

TPDB47662

ACE inhibitor (beta-CN fr.59-61) ACE inhibitors Antihypertensive Bitter Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47662
ACE inhibitor (beta-CN fr.59-61)
ACE inhibitors Antihypertensive Bitter Neuropeptide
Cardiometabolic peptides Neuroactive peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
VYP
Physicochemical Analysis
C19H27N3O5
ARNDCEQGHILKMFSTW
PYV
377.44
5.94
0
0
2
-0
-0.42
0.433
96.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
394.76
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
3
C19H27N3O5
377.44
5.94
-0
-0.42
0.433
377.4337
377.1944
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
288.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81(12), 3131-3138 (1998)
1998
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccc(cc1)O)C(C)C InChI=1S/C19H27N3O5/c1-11(2)16(20)17(24)21-14(10-12-5-7-13(23)8-6-12)18(25)22-9-3-4-15(22)19(26)27/h5-8,11,14-16,23H,3-4,9-10,20H2,1-2H3,(H,21,24)(H,26,27)/t14-,15-,16-/m0/s1 InChIKey: PMKQKNBISAOSRI-JYJNAYRXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Another value of peptide IC50(EC50)=44 (from Meisel H., Walsh D. J., Murray B., FitzGerald R. J. [2006]. ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315). Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Neuropeptide according to ChEMBL database EROP-Moscow database Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
288.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81(12), 3131-3138 (1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccc(cc1)O)C(C)C InChI=1S/C19H27N3O5/c1-11(2)16(20)17(24)21-14(10-12-5-7-13(23)8-6-12)18(25)22-9-3-4-15(22)19(26)27/h5-8,11,14-16,23H,3-4,9-10,20H2,1-2H3,(H,21,24)(H,26,27)/t14-,15-,16-/m0/s1 InChIKey: PMKQKNBISAOSRI-JYJNAYRXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Another value of peptide IC50(EC50)=44 (from Meisel H., Walsh D. J., Murray B., FitzGerald R. J. [2006]. ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315). Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Neuropeptide according to ChEMBL database EROP-Moscow database Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Additional Detail Fields 1 fields
3