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Peptide record

TPDB47661

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47661
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
GKP
Physicochemical Analysis
C13H24N4O4
ARNDCEQHILMFSTWYV
GKP
300.36
10.10
1
0
0
+1
1.45
-1.967
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C13H24N4O4
300.36
10.10
+1
1.45
-1.967
300.3531
300.1792
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
352.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81(12), 3131-3138 (1998)
1998
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCCN)(NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C13H24N4O4/c14-6-2-1-4-9(16-11(18)8-15)12(19)17-7-3-5-10(17)13(20)21/h9-10H,1-8,14-15H2,(H,16,18)(H,20,21)/t9-,10-/m0/s1 InChIKey=WDEHMRNSGHVNOH-UWVGGRQHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide is a fragment 18-20 of bovine beta-casein. Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Predicted as bitterness suppressing peptide according to the BIOPEP-UWM Virtual database (ID 137)
Evidence 2 Activity

Activity

IC50
Antihypertensive
352.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81(12), 3131-3138 (1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CCCCN)(NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C13H24N4O4/c14-6-2-1-4-9(16-11(18)8-15)12(19)17-7-3-5-10(17)13(20)21/h9-10H,1-8,14-15H2,(H,16,18)(H,20,21)/t9-,10-/m0/s1 InChIKey=WDEHMRNSGHVNOH-UWVGGRQHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide is a fragment 18-20 of bovine beta-casein. Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Predicted as bitterness suppressing peptide according to the BIOPEP-UWM Virtual database (ID 137)
Additional Detail Fields 1 fields
3