TPDB

3D PDB MODEL

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TPDB ID TPDB47660

Peptide_Name

ACE inhibitor

Activity

Antihypertensive iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

AHTPDB AHTpin Peptipedia iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (Antihypertensive and iDPPIV) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.

Sequence

RPK

FASTA

>TPDB47660|Antihypertensive;iDPPIV|length=3
RPK

Formula C17H33N7O4

Absent Amino Acids ANDCEQGHILMFSTWYV

Common Amino Acids RKP

Mass 399.49

PI 11.49

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +2

Boman Index 2.25

Hydrophobicity -3.333

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

3

Formula

C17H33N7O4

Mass

399.49

PI

11.49

Net Charge

+2

Boman Index

2.25

Hydrophobicity

-3.333

Chemical_Mass

399.4871

Monoisotopic_Mass

399.2587

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Silva S. V., Pihlanto A., Malcata F. X.

Title

Bioactive peptides in ovine and caprine cheeselike systems prepared with proteases from Cynara cardunculus. J. Dairy Sci., 89, 3336-3344, 2006

Year 2006

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C17H33N7O4/c18-8-2-1-6-12(16(27)28)23-14(25)13-7-4-10-24(13)15(26)11(19)5-3-9-22-17(20)21/h11-13H,1-10,18-19H2,(H,23,25)(H,27,28)(H4,20,21,22)/t11-,12-,13-/m0/s1 InChIKey=FVBZXNSRIDVYJS-AVGNSLFASA-N Anticancer peptide according to the BIOPEP-UWM database of bioactive peptides (ID 5472)

Number_of_Residues

3