Back to search

Peptide record

TPDB47655

ACE inhibitor from wheat germ hydrolysate ACE inhibitors Antihypertensive iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47655
ACE inhibitor from wheat germ hydrolysate
ACE inhibitors Antihypertensive iDPPIV
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and iDPPIV) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
IVY
Physicochemical Analysis
C20H31N3O5
ARNDCEQGHLKMFPSTW
IYV
393.48
5.94
0
0
3
-0
-1.18
2.467
226.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
378.67
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
3
C20H31N3O5
393.48
5.94
-0
-1.18
2.467
393.4760
393.2256
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.48 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Ueno T., Tanaka M., Matsui T., Matsumoto K.
Determination of antihypertensive small peptides, Val-Tyr and Ile-Val-Tyr, by fluorometric high-performance liquid chromatography combined with a double heart-cut column-swithcing technique. Anal. Sci., 2005, 21, 997-1000
2005
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)C(C)C)[C@H](CC)C InChI=1S/C20H31N3O5/c1-5-12(4)16(21)18(25)23-17(11(2)3)19(26)22-15(20(27)28)10-13-6-8-14(24)9-7-13/h6-9,11-12,15-17,24H,5,10,21H2,1-4H3,(H,22,26)(H,23,25)(H,27,28)/t12-,15-,16-,17-/m0/s1 InChiKey: QSXSHZIRKTUXNG-STECZYCISA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.48 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ueno T., Tanaka M., Matsui T., Matsumoto K.
Determination of antihypertensive small peptides, Val-Tyr and Ile-Val-Tyr, by fluorometric high-performance liquid chromatography combined with a double heart-cut column-swithcing technique. Anal. Sci., 2005, 21, 997-1000
2005
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)C(C)C)[C@H](CC)C InChI=1S/C20H31N3O5/c1-5-12(4)16(21)18(25)23-17(11(2)3)19(26)22-15(20(27)28)10-13-6-8-14(24)9-7-13/h6-9,11-12,15-17,24H,5,10,21H2,1-4H3,(H,22,26)(H,23,25)(H,27,28)/t12-,15-,16-,17-/m0/s1 InChiKey: QSXSHZIRKTUXNG-STECZYCISA-N
Additional Detail Fields 1 fields
3