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Peptide record

TPDB47653

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47653
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia and AHTPDB, with an available 3D structural model.
Sequence
AQL
Physicochemical Analysis
C14H26N4O5
RNDCEGHIKMFPSTWYV
AQL
330.38
6.02
0
0
2
-0
-0.15
0.700
163.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C14H26N4O5
330.38
6.02
-0
-0.15
0.700
330.3790
330.1897
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
57.54 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C14H26N4O5/c1-7(2)6-10(14(22)23)18-13(21)9(4-5-11(16)19)17-12(20)8(3)15/h7-10H,4-6,15H2,1-3H3,(H2,16,19)(H,17,20)(H,18,21)(H,22,23)/t8-,9-,10-/m0/s1 InChIKey: BLGHHPHXVJWCNK-GUBZILKMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
57.54 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C14H26N4O5/c1-7(2)6-10(14(22)23)18-13(21)9(4-5-11(16)19)17-12(20)8(3)15/h7-10H,4-6,15H2,1-3H3,(H2,16,19)(H,17,20)(H,18,21)(H,22,23)/t8-,9-,10-/m0/s1 InChIKey: BLGHHPHXVJWCNK-GUBZILKMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3