TPDB

3D PDB MODEL

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TPDB ID TPDB47647

Peptide_Name

ACE inhibitor from sea bream scales hydrolysate

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VIY

FASTA

>TPDB47647|ACE inhibitors;Antihypertensive|length=3
VIY

Formula C20H31N3O5

Absent Amino Acids ARNDCEQGHLKMFPSTW

Common Amino Acids IYV

Mass 393.48

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.18

Hydrophobicity 2.467

Aliphatic Index 226.67

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 378.67

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

3

Formula

C20H31N3O5

Mass

393.48

PI

5.94

Net Charge

-0

Boman Index

-1.18

Hydrophobicity

2.467

Chemical_Mass

393.4760

Monoisotopic_Mass

393.2256

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 7.50 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Qian Z.-L., Jung W.-K., Lee S.-H., Byun H.-G., Kim S.-K.

Title

Antihypertensive effect of an angiotensin I-converting enzyme inhibitory peptide from bulfrog (Rana catesbeiana Shaw) muscle protein in spontaneously hypertensive rats. Process Biochemistry, 42, 1443-1448

Year 2007

Literature Source Journal

Other

Number of Residues 3

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 7.50 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Qian Z.-L., Jung W.-K., Lee S.-H., Byun H.-G., Kim S.-K.

Title

Antihypertensive effect of an angiotensin I-converting enzyme inhibitory peptide from bulfrog (Rana catesbeiana Shaw) muscle protein in spontaneously hypertensive rats. Process Biochemistry, 42, 1443-1448

Year 2007

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Number_of_Residues

3