TPDB

3D PDB MODEL

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TPDB ID TPDB47645

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.

Sequence

IFL

FASTA

>TPDB47645|ACE inhibitors;Antihypertensive|length=3
IFL

Formula C21H33N3O4

Absent Amino Acids ARNDCEQGHKMPSTWYV

Common Amino Acids ILF

Mass 391.51

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.00

Hydrophobicity 3.700

Aliphatic Index 260.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

3

Formula

C21H33N3O4

Mass

391.51

PI

6.02

Net Charge

-0

Boman Index

-2.00

Hydrophobicity

3.700

Chemical_Mass

391.5031

Monoisotopic_Mass

391.2463

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 44.67 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Kuba M., Tanaka K., Tawata S., Takeda Y., Yasuda M.

Title

Angiotensin I-converting enzyme inhibitory peptides isolated from tofuyo fermented soybean food. Biosci. Biotech. Biochem., 67, 1278-1283, 2003

Year 2003

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccccc1)[C@H](CC)C InChI=1S/C21H33N3O4/c1-5-14(4)18(22)20(26)23-16(12-15-9-7-6-8-10-15)19(25)24-17(21(27)28)11-13(2)3/h6-10,13-14,16-18H,5,11-12,22H2,1-4H3,(H,23,26)(H,24,25)(H,27,28)/t14-,16-,17-,18-/m0/s1 InChIKey: XLXPYSDGMXTTNQ-DKIMLUQUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 44.67 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB FermFooDB

Authors Kuba M., Tanaka K., Tawata S., Takeda Y., Yasuda M.

Title

Angiotensin I-converting enzyme inhibitory peptides isolated from tofuyo fermented soybean food. Biosci. Biotech. Biochem., 67, 1278-1283, 2003

Year 2003

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccccc1)[C@H](CC)C InChI=1S/C21H33N3O4/c1-5-14(4)18(22)20(26)23-16(12-15-9-7-6-8-10-15)19(25)24-17(21(27)28)11-13(2)3/h6-10,13-14,16-18H,5,11-12,22H2,1-4H3,(H,23,26)(H,24,25)(H,27,28)/t14-,16-,17-,18-/m0/s1 InChIKey: XLXPYSDGMXTTNQ-DKIMLUQUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

3