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Peptide record

TPDB47635

ACE inhibitor from porcine myosin (80-82) ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47635
ACE inhibitor from porcine myosin (80-82)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
NPP
Physicochemical Analysis
C14H22N4O5
ARDCEQGHILKMFSTWYV
P
326.35
6.02
0
0
0
-0
1.32
-2.233
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C14H22N4O5
326.35
6.02
-0
1.32
-2.233
326.3474
326.1585
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
290.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Arihara K., Nakashima Y., Mukai T., Ishikawa S., Itoh M.
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle. Meat Sci., 57, 319-324, 2001
2001
Journal

Other

3
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released from myosin by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Evidence 2 Activity

Activity

IC50
Antihypertensive
290.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Arihara K., Nakashima Y., Mukai T., Ishikawa S., Itoh M.
Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle. Meat Sci., 57, 319-324, 2001
2001
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide released from myosin by simulated gastric juice. Terashima M., Baba T., Ikemoto N., Katayama M., Morimoto T., Matsumura S., 2010, Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat. J. Agric. Food Chem., 58, 7432-7436
Additional Detail Fields 1 fields
3