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Peptide record

TPDB47632

ACE inhibitor ACE inhibitors Antihypertensive Bitter standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47632
ACE inhibitor
ACE inhibitors Antihypertensive Bitter
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Bitter) peptide sequence curated from Peptipedia, AHTPDB, and Tastepeptides-Meta, with an available 3D structural model.
Sequence
GLY
Physicochemical Analysis
C17H25N3O5
ARNDCEQHIKMFPSTWV
GLY
351.40
5.94
0
0
2
-0
-1.49
0.700
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
424.02
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C17H25N3O5
351.40
5.94
-0
-1.49
0.700
351.3965
351.1788
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.91 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C17H25N3O5/c1-10(2)7-13(19-15(22)9-18)16(23)20-14(17(24)25)8-11-3-5-12(21)6-4-11/h3-6,10,13-14,21H,7-9,18H2,1-2H3,(H,19,22)(H,20,23)(H,24,25)/t13-,14-/m0/s1 InChIKey: AFWYPMDMDYCKMD-KBPBESRZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide regulating phosphoinositol metabolism according to the BIOPEP-UWM database of bioactive peptides (ID 2739) Immunostimulating peptide according to the EROP-Moscow database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids, the ChEMBL database
Evidence 2 Activity

Activity

IC50
Antihypertensive
8.91 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C17H25N3O5/c1-10(2)7-13(19-15(22)9-18)16(23)20-14(17(24)25)8-11-3-5-12(21)6-4-11/h3-6,10,13-14,21H,7-9,18H2,1-2H3,(H,19,22)(H,20,23)(H,24,25)/t13-,14-/m0/s1 InChIKey: AFWYPMDMDYCKMD-KBPBESRZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide regulating phosphoinositol metabolism according to the BIOPEP-UWM database of bioactive peptides (ID 2739) Immunostimulating peptide according to the EROP-Moscow database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids, the ChEMBL database
Additional Detail Fields 1 fields
3