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Peptide record

TPDB47626

ACE inhibitor Hypotensive peptide ACE inhibitors Antihypertensive Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47626
ACE inhibitor Hypotensive peptide
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
HHL
Physicochemical Analysis
C18H27N7O4
ARNDCEQGIKMFPSTWYV
H
405.46
8.00
2
0
1
+0
1.36
-0.867
130.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C18H27N7O4
405.46
8.00
+0
1.36
-0.867
405.4504
405.2119
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
5.43 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Shin Z. I., Yu R., Park S. A., Chung D. K., Ahn C. W., Nam H. S., Kim K. S., Lee H. J.
His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo. J. Agric. Food Chem., 49, 3004-3009, 2001
2001
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C18H27N7O4/c1-10(2)3-15(18(28)29)25-17(27)14(5-12-7-21-9-23-12)24-16(26)13(19)4-11-6-20-8-22-11/h6-10,13-15H,3-5,19H2,1-2H3,(H,20,22)(H,21,23)(H,24,26)(H,25,27)(H,28,29)/t13-,14-,15-/m0/s1 InChIKey=PMWSGVRIMIFXQH-KKUMJFAQSA-N Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
5.43 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Shin Z. I., Yu R., Park S. A., Chung D. K., Ahn C. W., Nam H. S., Kim K. S., Lee H. J.
His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo. J. Agric. Food Chem., 49, 3004-3009, 2001
2001
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C18H27N7O4/c1-10(2)3-15(18(28)29)25-17(27)14(5-12-7-21-9-23-12)24-16(26)13(19)4-11-6-20-8-22-11/h6-10,13-15H,3-5,19H2,1-2H3,(H,20,22)(H,21,23)(H,24,26)(H,25,27)(H,28,29)/t13-,14-,15-/m0/s1 InChIKey=PMWSGVRIMIFXQH-KKUMJFAQSA-N Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides the DFBP database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Hypotensive activity in rats
hypotensive
hyp

Source & Reference

AHTPDB FermFooDB
Shin Z. I., Yu R., Park S. A., Chung D. K., Ahn C. W., Nam H. S., Kim K. S., Lee H. J.
His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo. J. Agric. Food Chem., 49, 3004-3009, 2001
2021
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C18H27N7O4/c1-10(2)3-15(18(28)29)25-17(27)14(5-12-7-21-9-23-12)24-16(26)13(19)4-11-6-20-8-22-11/h6-10,13-15H,3-5,19H2,1-2H3,(H,20,22)(H,21,23)(H,24,26)(H,25,27)(H,28,29)/t13-,14-,15-/m0/s1 InChIKey=PMWSGVRIMIFXQH-KKUMJFAQSA-N Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides the DFBP database the EROP-Moscow database the PlantPepDB database
Additional Detail Fields 1 fields
3