Back to search

Peptide record

TPDB47619

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47619
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
HHT
Physicochemical Analysis
C16H23N7O5
ARNDCEQGILKMFPSWYV
H
393.40
8.00
2
0
0
+0
2.06
-2.367
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H23N7O5
393.40
8.00
+0
2.06
-2.367
393.3968
393.1756
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
794.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)O InChI=1S/C16H23N7O5/c1-8(24)13(16(27)28)23-15(26)12(3-10-5-19-7-21-10)22-14(25)11(17)2-9-4-18-6-20-9/h4-8,11-13,24H,2-3,17H2,1H3,(H,18,20)(H,19,21)(H,22,25)(H,23,26)(H,27,28)/t8-,11+,12+,13+/m1/s1 InChIKey: CNHSMSFYVARZLI-YJRXYDGGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
794.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)O InChI=1S/C16H23N7O5/c1-8(24)13(16(27)28)23-15(26)12(3-10-5-19-7-21-10)22-14(25)11(17)2-9-4-18-6-20-9/h4-8,11-13,24H,2-3,17H2,1H3,(H,18,20)(H,19,21)(H,22,25)(H,23,26)(H,27,28)/t8-,11+,12+,13+/m1/s1 InChIKey: CNHSMSFYVARZLI-YJRXYDGGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3