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Peptide record

TPDB47610

ACE inhibitor Peptide 2 ACE inhibitors Antihypertensive Bitter Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47610
ACE inhibitor Peptide 2
ACE inhibitors Antihypertensive Bitter Selfassembly
Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
LG
Physicochemical Analysis
C8H16N2O3
ARNDCEQHIKMFPSTWYV
GL
188.23
6.02
0
0
1
-0
-0.55
1.700
195.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H16N2O3
188.23
6.02
-0
-0.55
1.700
188.2236
188.1157
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

21833387
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanosphere Spherical structure
pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
Selfassembly; Nanostructure=Nanosphere; Spherical structure; Trigger=pH: 6.96; temperature: 37 °C; solvent: Water; concentration: 0.06mmol
FE - SEM (Field Emission Scanning Electron Microscopy), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
Selfassembly
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8800.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
1980
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)O)CC(C)C InChI=1S/C8H16N2O3/c1-5(2)3-6(9)8(13)10-4-7(11)12/h5-6H,3-4,9H2,1-2H3,(H,10,13)(H,11,12)/t6-/m0/s1 InChIKey: LESXFEZIFXFIQR-LURJTMIESA-N Inhibitor of Leucyl aminopeptidase (EC 3.4.11.1) (MEROPS ID: M17.001) according to BRENDA database Inhibitor of Polar-amino-acid-transporting ATPase (EC 3.6.3.21) according to BRENDA database Inhibitor of citrulline uptake in yeasts according to ChEMBL database PubChem database Bitter peptide according to BIOPEP database of sensory peptides and amino acids ChEMBL database PubChem database
Evidence 2 Activity

Activity

IC50
Antihypertensive
8800.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)O)CC(C)C InChI=1S/C8H16N2O3/c1-5(2)3-6(9)8(13)10-4-7(11)12/h5-6H,3-4,9H2,1-2H3,(H,10,13)(H,11,12)/t6-/m0/s1 InChIKey: LESXFEZIFXFIQR-LURJTMIESA-N Inhibitor of Leucyl aminopeptidase (EC 3.4.11.1) (MEROPS ID: M17.001) according to BRENDA database Inhibitor of Polar-amino-acid-transporting ATPase (EC 3.6.3.21) according to BRENDA database Inhibitor of citrulline uptake in yeasts according to ChEMBL database PubChem database Bitter peptide according to BIOPEP database of sensory peptides and amino acids ChEMBL database PubChem database
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanosphere Spherical structure Trigger=pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
Nanosphere Spherical structure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
FE - SEM (Field Emission Scanning Electron Microscopy), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
21833387
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
21833387
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly