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Peptide record

TPDB47606

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Bitter iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47606
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Bitter iDPPIV
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
RG
Physicochemical Analysis
C8H17N5O3
ANDCEQHILKMFPSTWYV
RG
231.25
11.05
1
0
0
+1
0.82
-2.450
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H17N5O3
231.25
11.05
+1
0.82
-2.450
231.2516
231.1328
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H. S., Wang F. L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence. Journal of Biological Chemistry, 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)NCC(O)=O InChI=1S/C8H17N5O3/c9-5(2-1-3-12-8(10)11)7(16)13-4-6(14)15/h5H,1-4,9H2,(H,13,16)(H,14,15)(H4,10,11,12)/t5-/m0/s1 InChIKey=XUUXCWCKKCZEAW-YFKPBYRVSA-N Inhibitor of the Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8882) Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 8) Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 422)
Evidence 2 Activity

Activity

IC50
Antihypertensive
1200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H. S., Wang F. L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence. Journal of Biological Chemistry, 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)NCC(O)=O InChI=1S/C8H17N5O3/c9-5(2-1-3-12-8(10)11)7(16)13-4-6(14)15/h5H,1-4,9H2,(H,13,16)(H,14,15)(H4,10,11,12)/t5-/m0/s1 InChIKey=XUUXCWCKKCZEAW-YFKPBYRVSA-N Inhibitor of the Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8882) Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 8) Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 422)
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73
2015
Journal

Other

2
BIOPEP-UWM database bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O InChI=1S/C8H17N5O3/c9-5(2-1-3-12-8(10)11)7(16)13-4-6(14)15/h5H,1-4,9H2,(H,13,16)(H,14,15)(H4,10,11,12)/t5-/m0/s1 InChIKey: XUUXCWCKKCZEAW-YFKPBYRVSA-N Inhibitor of the Leucyltransferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of the angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BIOPEP-UWM database of bioactive peptides (ID 9173), the EROP-Moscow database Inhibitor of citrulline uptake in yeasts according to the ChEMBL database the PubChem database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 8) Salty taste enhancing peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 422)
Additional Detail Fields 1 fields
2