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Peptide record

TPDB47605

ACE inhibitor ACE inhibitors Antihypertensive Bitter standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47605
ACE inhibitor
ACE inhibitors Antihypertensive Bitter
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Bitter) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
IG
Physicochemical Analysis
C8H16N2O3
ARNDCEQHLKMFPSTWYV
GI
188.23
6.02
0
0
1
-0
-0.30
2.050
195.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H16N2O3
188.23
6.02
-0
-0.30
2.050
188.2236
188.1157
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)O)[C@H](CC)C InChI=1S/C8H16N2O3/c1-3-5(2)7(9)8(13)10-4-6(11)12/h5,7H,3-4,9H2,1-2H3,(H,10,13)(H,11,12)/t5-,7-/m0/s1 InChIKey: UCGDDTHMMVWVMV-FSPLSTOPSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 164) the ChEMBL database the PubChem database
Evidence 2 Activity

Activity

IC50
Antihypertensive
1200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)NCC(=O)O)[C@H](CC)C InChI=1S/C8H16N2O3/c1-3-5(2)7(9)8(13)10-4-6(11)12/h5,7H,3-4,9H2,1-2H3,(H,10,13)(H,11,12)/t5-,7-/m0/s1 InChIKey: UCGDDTHMMVWVMV-FSPLSTOPSA-N Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 164) the ChEMBL database the PubChem database
Additional Detail Fields 1 fields
2