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Peptide record

TPDB47604

ACE inhibitor GlyAsp perylene bisimide (PBI) ACE inhibitors Antihypertensive Umami Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47604
ACE inhibitor GlyAsp perylene bisimide (PBI)
ACE inhibitors Antihypertensive Umami Selfassembly
Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Umami, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GD
Physicochemical Analysis
C6H10N2O5
ARNCEQHILKMFPSTWYV
DG
190.16
3.10
0
1
0
-1
1.24
-1.950
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C6H10N2O5
190.16
3.10
-1
1.24
-1.950
190.1536
190.0587
Self-Assembly Information 2 records
Record 1 Selfassembly

Source

29384183
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber and Nanosphere nanofibers and nanospHeres
temperature: 34.1°C solvent: PBS buffer solution concentration: 2.0 mM
Selfassembly; Nanostructure=Nanofiber and Nanosphere; nanofibers and nanospHeres; Trigger=temperature: 34.1°C; solvent: PBS buffer solution; concentration: 2.0 mM
Transmission Electron Microscopy (TEM)
Selfassembly
Record 2 Selfassembly

Source

30280722
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanostructure nanostructures
pH: 5 to 7.4 temperature: Room temperature solvent: 470 nm in aqueous buffered solution concentration: 10 mM Tris
Selfassembly; Nanostructure=Nanostructure; nanostructures; Trigger=pH: 5 to 7.4; temperature: Room temperature; solvent: 470 nm in aqueous buffered solution; concentration: 10 mM Tris
light scattering, NMR, IR, and TEM
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
9200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C6H10N2O5/c7-2-4(9)8-3(6(12)13)1-5(10)11/h3H,1-2,7H2,(H,8,9)(H,10,11)(H,12,13)/t3-/m0/s1 InChIKey=SCCPDJAQCXWPTF-VKHMYHEASA-N Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) according to the BIOPEP-UWM database of bioactive peptides
Evidence 2 Activity

Activity

IC50
Antihypertensive
9200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C6H10N2O5/c7-2-4(9)8-3(6(12)13)1-5(10)11/h3H,1-2,7H2,(H,8,9)(H,10,11)(H,12,13)/t3-/m0/s1 InChIKey=SCCPDJAQCXWPTF-VKHMYHEASA-N Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.001) according to the BIOPEP-UWM database of bioactive peptides
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber and Nanosphere nanofibers and nanospHeres Trigger=temperature: 34.1°C solvent: PBS buffer solution concentration: 2.0 mM
Nanofiber and Nanosphere nanofibers and nanospHeres

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 34.1°C solvent: PBS buffer solution concentration: 2.0 mM
Transmission Electron Microscopy (TEM)
29384183
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanostructure nanostructures Trigger=pH: 5 to 7.4 temperature: Room temperature solvent: 470 nm in aqueous buffered solution concentration: 10 mM Tris
Nanostructure nanostructures

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 5 to 7.4 temperature: Room temperature solvent: 470 nm in aqueous buffered solution concentration: 10 mM Tris
light scattering, NMR, IR, and TEM
30280722
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
temperature: 34.1°C solvent: PBS buffer solution concentration: 2.0 mM pH: 5 to 7.4 temperature: Room temperature solvent: 470 nm in aqueous buffered solution concentration: 10 mM Tris
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
29384183 30280722
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly