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Peptide record

TPDB47598

ACE inhibitor IF isoleucine–Phenylalanine NH2-Ile-Phe-COOH ACE inhibitors Antihypertensive Bitter Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47598
ACE inhibitor IF isoleucine–Phenylalanine NH2-Ile-Phe-COOH
ACE inhibitors Antihypertensive Bitter Selfassembly
Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
FermFooDB Peptipedia AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IF
Physicochemical Analysis
C15H22N2O3
ARNDCEQGHLKMPSTWYV
IF
278.35
6.02
0
0
2
-0
-1.44
3.650
195.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C15H22N2O3
278.35
6.02
-0
-1.44
3.650
278.3459
278.1625
Self-Assembly Information 3 records
Record 1 Selfassembly

Source

17172307
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Nanofibrils
pH: 5.8 temperature: Room temperature solvent: Aqueous dispersion concentration: 2% (w/v)
Selfassembly; Nanostructure=Nanofiber; Nanofibrils; Trigger=pH: 5.8; temperature: Room temperature; solvent: Aqueous dispersion; concentration: 2% (w/v)
Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM)
Selfassembly
Record 2 Selfassembly

Source

23795243
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Fibers
temperature: 30 °C solvent: Water concentration: 0.4M
Selfassembly; Nanostructure=Nanofiber; Fibers; Trigger=temperature: 30 °C; solvent: Water; concentration: 0.4M
Insilico method: MARTINI coarse - grained molecular dynamic
Selfassembly
Record 3 Selfassembly

Source

30132003
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel
temperature: 323 K to 283 K solvent: H2O:D2O concentration: 95% : 5%
Selfassembly; Nanostructure=Hydrogel; Trigger=temperature: 323 K to 283 K; solvent: H2O:D2O; concentration: 95% : 5%
NMR
Selfassembly
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
930.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)[C@H](CC)C InChI=1S/C15H22N2O3/c1-3-10(2)13(16)14(18)17-12(15(19)20)9-11-7-5-4-6-8-11/h4-8,10,12-13H,3,9,16H2,1-2H3,(H,17,18)(H,19,20)/t10-,12-,13-/m0/s1 InChIKey: WMDZARSFSMZOQO-DRZSPHRISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 53)
Evidence 2 Activity

Activity

IC50
Antihypertensive
930.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)[C@H](CC)C InChI=1S/C15H22N2O3/c1-3-10(2)13(16)14(18)17-12(15(19)20)9-11-7-5-4-6-8-11/h4-8,10,12-13H,3,9,16H2,1-2H3,(H,17,18)(H,19,20)/t10-,12-,13-/m0/s1 InChIKey: WMDZARSFSMZOQO-DRZSPHRISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 53)
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Nanofibrils Trigger=pH: 5.8 temperature: Room temperature solvent: Aqueous dispersion concentration: 2% (w/v)
Nanofiber Nanofibrils

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 5.8 temperature: Room temperature solvent: Aqueous dispersion concentration: 2% (w/v)
Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM)
17172307
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Fibers Trigger=temperature: 30 °C solvent: Water concentration: 0.4M
Nanofiber Fibers

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 30 °C solvent: Water concentration: 0.4M
Insilico method: MARTINI coarse - grained molecular dynamic
23795243
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Trigger=temperature: 323 K to 283 K solvent: H2O:D2O concentration: 95% : 5%
Hydrogel

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 323 K to 283 K solvent: H2O:D2O concentration: 95% : 5%
NMR
30132003
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 5.8 temperature: Room temperature solvent: Aqueous dispersion concentration: 2% (w/v) temperature: 30 °C solvent: Water concentration: 0.4M temperature: 323 K to 283 K solvent: H2O:D2O concentration: 95% : 5%
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
17172307 23795243 30132003
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly