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Peptide record

TPDB47596

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47596
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GQ
Physicochemical Analysis
C7H13N3O4
ARNDCEHILKMFPSTWYV
QG
203.20
6.02
0
0
0
-0
0.59
-1.950
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C7H13N3O4
203.20
6.02
-0
0.59
-1.950
203.1953
203.0903
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
7000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14)/t4-/m0/s1 InChIKey: PNMUAGGSDZXTHX-BYPYZUCNSA-N Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID 2890) the ChEMBL database
Evidence 2 Activity

Activity

IC50
Antihypertensive
7000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14)/t4-/m0/s1 InChIKey: PNMUAGGSDZXTHX-BYPYZUCNSA-N Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID 2890) the ChEMBL database
Additional Detail Fields 1 fields
2