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Peptide record

TPDB47593

ACE inhibitor ACE inhibitors Antihypertensive Bitter standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47593
ACE inhibitor
ACE inhibitors Antihypertensive Bitter
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Bitter) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GR
Physicochemical Analysis
C8H17N5O3
ANDCEQHILKMFPSTWYV
RG
231.25
11.05
1
0
0
+1
0.82
-2.450
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C8H17N5O3
231.25
11.05
+1
0.82
-2.450
231.2516
231.1328
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: C(C[C@@H](C(=O)O)NC(=O)CN)CNC(=N)N InChI=1S/C8H17N5O3/c9-4-6(14)13-5(7(15)16)2-1-3-12-8(10)11/h5H,1-4,9H2,(H,13,14)(H,15,16)(H4,10,11,12)/t5-/m0/s1 InChIKey: JLXVRFDTDUGQEE-YFKPBYRVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of the peptide IC50(EC50)=162.2uM. Sentandreu M. A., Toldra F., 2007. Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chemistry, 102, 2, 511-515. Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
3200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: C(C[C@@H](C(=O)O)NC(=O)CN)CNC(=N)N InChI=1S/C8H17N5O3/c9-4-6(14)13-5(7(15)16)2-1-3-12-8(10)11/h5H,1-4,9H2,(H,13,14)(H,15,16)(H4,10,11,12)/t5-/m0/s1 InChIKey: JLXVRFDTDUGQEE-YFKPBYRVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of the peptide IC50(EC50)=162.2uM. Sentandreu M. A., Toldra F., 2007. Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chemistry, 102, 2, 511-515. Bitter peptide according to BIOPEP-UWM database of sensory peptides and amino acids
Additional Detail Fields 1 fields
2