Back to search

Peptide record

TPDB47591

ACE inhibitor C 3 -GA dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) glutaraldehyde ACE inhibitors Antihypertensive iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB47591
ACE inhibitor C 3 -GA dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) glutaraldehyde
ACE inhibitors Antihypertensive iDPPIV Selfassembly
Cardiometabolic peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, iDPPIV, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GA
Physicochemical Analysis
C5H10N2O3
RNDCEQHILKMFPSTWYV
AG
146.15
6.02
0
0
1
-0
-0.16
0.700
50.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C5H10N2O3
146.15
6.02
-0
-0.16
0.700
146.1441
146.0689
Self-Assembly Information 3 records
Record 1 Selfassembly

Source

24863871
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Long helical Nanofibers
temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 5.48 √ó 10 ‚àí3 mol/L
Selfassembly; Nanostructure=Nanofiber; Long helical Nanofibers; Trigger=temperature: > 25 °C; solvent: Tetrahydrofuran (THF); concentration: 5.48 √ó 10 ‚àí3 mol/L
AFM (Atomic Force Microscopy)
Selfassembly
Record 2 Selfassembly

Source

24863871
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanofiber Supramolecular Nanofibers
temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 2.28 √ó 10 ‚àí4 mol/L
Selfassembly; Nanostructure=Nanofiber; Supramolecular Nanofibers; Trigger=temperature: > 25 °C; solvent: Tetrahydrofuran (THF); concentration: 2.28 √ó 10 ‚àí4 mol/L
AFM (Atomic Force Microscopy)
Selfassembly
Record 3 Selfassembly

Source

30175529
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
nanoparticles
solvent: 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) concentration: 4 mL of 25% (w/v)
Selfassembly; Nanostructure=nanoparticles; Trigger=solvent: 1,1,1,3,3,3-hexafluoro-2-propanol (HFP); concentration: 4 mL of 25% (w/v)
(FTIR) and (ESI MS)
Selfassembly
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2000.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1)(MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C5H10N2O3/c1-3(5(9)10)7-4(8)2-6/h3H,2,6H2,1H3,(H,7,8)(H,9,10)/t3-/m0/s1 InChIKey=VPZXBVLAVMBEQI-VKHMYHEASA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8524) the BRENDA database the DFBP database Inhibitor of Alanine carboxypeptidase (EC 3.4.17.6) (MEROPS ID: M9E.002) according to the BRENDA database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides
Evidence 2 Activity

Activity

IC50
Antihypertensive
2000.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1)(MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C5H10N2O3/c1-3(5(9)10)7-4(8)2-6/h3H,2,6H2,1H3,(H,7,8)(H,9,10)/t3-/m0/s1 InChIKey=VPZXBVLAVMBEQI-VKHMYHEASA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8524) the BRENDA database the DFBP database Inhibitor of Alanine carboxypeptidase (EC 3.4.17.6) (MEROPS ID: M9E.002) according to the BRENDA database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hikida A., Ito K., Motoyama T., Kato R., Kawarasaki Y.
Systematic analysis of a dipeptide library for inhibitor development using human dipeptidyl peptidase IV produced by a Saccharomyces cerevisiae expression system. Biochem. Biophys. Res. Commun., 430, 1217-1222, 2013
2013
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C5H10N2O3/c1-3(5(9)10)7-4(8)2-6/h3H,2,6H2,1H3,(H,7,8)(H,9,10)/t3-/m0/s1 InChIKey=VPZXBVLAVMBEQI-VKHMYHEASA-N Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1)(MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 7598) the ChEMBL database the DFBP database the EROP-Moscow database Inhibitor of Alanine carboxypeptidase (EC 3.4.17.6) (MEROPS ID: M9E.002) according to the BRENDA database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Long helical Nanofibers Trigger=temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 5.48 √ó 10 ‚àí3 mol/L
Nanofiber Long helical Nanofibers

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 5.48 √ó 10 ‚àí3 mol/L
AFM (Atomic Force Microscopy)
24863871
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber Supramolecular Nanofibers Trigger=temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 2.28 √ó 10 ‚àí4 mol/L
Nanofiber Supramolecular Nanofibers

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 2.28 √ó 10 ‚àí4 mol/L
AFM (Atomic Force Microscopy)
24863871
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 6 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=nanoparticles Trigger=solvent: 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) concentration: 4 mL of 25% (w/v)
nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
solvent: 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) concentration: 4 mL of 25% (w/v)
(FTIR) and (ESI MS)
30175529
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1703 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
temperature: > 25 °C solvent: Tetrahydrofuran (THF) concentration: 5.48 √ó 10 ‚àí3 mol/L temperature: > 25 °C concentration: 2.28 √ó 10 ‚àí4 mol/L solvent: 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) concentration: 4 mL of 25% (w/v)
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database. SAPdb ID 1703 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
2
24863871 30175529
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly