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Peptide record

TPDB47584

ACE inhibitor Asp-Phe (DF) ACE inhibitors Antihypertensive Bitter Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47584
ACE inhibitor Asp-Phe (DF)
ACE inhibitors Antihypertensive Bitter Selfassembly
Cardiometabolic peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
DF
Physicochemical Analysis
C13H16N2O5
ARNCEQGHILKMPSTWYV
DF
280.28
3.10
0
1
1
-1
0.10
-0.350
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C13H16N2O5
280.28
3.10
-1
0.10
-0.350
280.2759
280.1055
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

28414150
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
pH: 7.4 temperature: Room temperature solvent: phosphate buffer concentration: 5 mM
Selfassembly; Nanostructure=Nanoparticles; Trigger=pH: 7.4; temperature: Room temperature; solvent: phosphate buffer; concentration: 5 mM
Transmission Electron Microscopy (TEM)
Selfassembly
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
363.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1 InChIKey: YZQCXOFQZKCETR-UWVGGRQHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Diaminopimelate dehydrogenase (EC 1.4.1.16) according to the BRENDA database Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) according to the BRENDA database Bitter peptide according to the ChEMBL database the PubChem database
Evidence 2 Activity

Activity

IC50
Antihypertensive
363.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1 InChIKey: YZQCXOFQZKCETR-UWVGGRQHSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Diaminopimelate dehydrogenase (EC 1.4.1.16) according to the BRENDA database Inhibitor of Glutamate carboxypeptidase II (EC 3.4.17.21) according to the BRENDA database Bitter peptide according to the ChEMBL database the PubChem database
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=pH: 7.4 temperature: Room temperature solvent: phosphate buffer concentration: 5 mM
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.4 temperature: Room temperature solvent: phosphate buffer concentration: 5 mM
Transmission Electron Microscopy (TEM)
28414150
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1915 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
pH: 7.4 temperature: Room temperature solvent: phosphate buffer concentration: 5 mM
None specified
SAPdb ID 1915 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
2
28414150
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly