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Peptide record

TPDB47583

ACE inhibitor Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Tyr-Pro ACE inhibitors Antihypertensive Bitter Blood-Brain Barrier iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47583
ACE inhibitor Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Tyr-Pro
ACE inhibitors Antihypertensive Bitter Blood-Brain Barrier iDPPIV
Cardiometabolic peptides Delivery and barrier-penetrating peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
TP
Physicochemical Analysis
C9H16N2O4
ARNDCEQGHILKMFSWYV
PT
216.24
6.02
0
0
0
-0
0.59
-1.150
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C9H16N2O4
216.24
6.02
-0
0.59
-1.150
216.2337
Linear
216.1106
Similarity
Tyr-Pro
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
288.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)[C@H](O)C InChI=1S/C9H16N2O4/c1-5(12)7(10)8(13)11-4-2-3-6(11)9(14)15/h5-7,12H,2-4,10H2,1H3,(H,14,15)/t5-,6+,7+/m1/s1 InChIKey: QOLYAJSZHIJCTO-VQVTYTSYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database (ID 8503) Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 526)
Evidence 2 Activity

Activity

IC50
Antihypertensive
288.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)[C@H](O)C InChI=1S/C9H16N2O4/c1-5(12)7(10)8(13)11-4-2-3-6(11)9(14)15/h5-7,12H,2-4,10H2,1H3,(H,14,15)/t5-,6+,7+/m1/s1 InChIKey: QOLYAJSZHIJCTO-VQVTYTSYSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database (ID 8503) Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 526)
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00353 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
Permeability
Evidence 4 Activity

Activity

Blood-Brain Barrier
10.5

Assay & Model

Origin/Source
Brain/perfusate ratio

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
Permeability
Evidence 5 Activity

Activity

IC50
iDPPIV
2370.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Production of dipeptidyl peptidase IV inhibitory peptides from defated rice bran. Food Chem., 134, 797-802, 2012
2012
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C9H16N2O4/c1-5(12)7(10)8(13)11-4-2-3-6(11)9(14)15/h5-7,12H,2-4,10H2,1H3,(H,14,15)/t5?,6-,7-/m0/s1 InChIKey: QOLYAJSZHIJCTO-BYRXKDITSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database (ID 9073) the BRENDA database the ChEMBL database Sour peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 526)
Additional Detail Fields 2 fields
in situ brain perfusion
2