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Peptide record

TPDB47579

ACE inhibitor from sake lees Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Anti-inflammatory Antihypertensive Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47579
ACE inhibitor from sake lees Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Anti-inflammatory Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Immunity and inflammation peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YW
Physicochemical Analysis
C20H21N3O4
ARNDCEQGHILKMFPSTV
WY
367.40
5.94
0
0
2
-0
-2.79
-1.100
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6990
1902.54
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
2
C20H21N3O4
367.40
5.94
-0
-2.79
-1.100
367.3976
367.1527
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
10.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58(10), 1767-1771 (1994)
1994
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O InChI=1S/C20H21N3O4/c21-16(9-12-5-7-14(24)8-6-12)19(25)23-18(20(26)27)10-13-11-22-17-4-2-1-3-15(13)17/h1-8,11,16,18,22,24H,9-10,21H2,(H,23,25)(H,26,27)/t16-,18-/m0/s1 InChIKey=BMPPMAOOKQJYIP-WMZOPIPTSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8947) Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9868)
Evidence 2 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
Anti-inflammatory
anti inflammatory
ai

Source & Reference

NA
Wang S., Zheng L., Zhao T., Zhang Q., Liu Y., Sun B., Su G., Zhao M.
Inhibitory effects of walnut (Juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice. J. Agric. Food Chem., 68, 2381-2392, 2020
2020
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C15H27N5O6/c1-7(2)5-10(20-13(23)8(16)6-12(18)22)14(24)19-9(15(25)26)3-4-11(17)21/h7-10H,3-6,16H2,1-2H3,(H2,17,21)(H2,18,22)(H,19,24)(H,20,23)(H,25,26)/t8-,9-,10-/m0/s1 InChIKey=HFPXZWPUVFVNLL-GUBZILKMSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 3488) the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8947)
Evidence 3 Activity

Activity

IC50
Antihypertensive
10.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58(10), 1767-1771 (1994)
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O InChI=1S/C20H21N3O4/c21-16(9-12-5-7-14(24)8-6-12)19(25)23-18(20(26)27)10-13-11-22-17-4-2-1-3-15(13)17/h1-8,11,16,18,22,24H,9-10,21H2,(H,23,25)(H,26,27)/t16-,18-/m0/s1 InChIKey=BMPPMAOOKQJYIP-WMZOPIPTSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8947) Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9868)
Evidence 4 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O InChI=1S/C20H21N3O4/c21-16(9-12-5-7-14(24)8-6-12)19(25)23-18(20(26)27)10-13-11-22-17-4-2-1-3-15(13)17/h1-8,11,16,18,22,24H,9-10,21H2,(H,23,25)(H,26,27)/t16-,18-/m0/s1 InChIKey=BMPPMAOOKQJYIP-WMZOPIPTSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 3488) the EROP-Moscow database Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9868)
Additional Detail Fields 1 fields
2