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Peptide record

TPDB47573

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Bitter Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47573
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Bitter Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YG
Physicochemical Analysis
C11H14N2O4
ARNDCEQHILKMFPSTWV
GY
238.24
5.94
0
0
1
-0
-0.93
-0.850
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
625.41
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C11H14N2O4
238.24
5.94
-0
-0.93
-0.850
238.2393
238.0950
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1523.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996
1996
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: c1cc(ccc1C[C@@H](C(=O)NCC(=O)O)N)O InChI=1S/C11H14N2O4/c12-9(11(17)13-6-10(15)16)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,17)(H,15,16)/t9-/m0/s1 InChIKey: HPYDSVWYXXKHRD-VIFPVBQESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide known as alpha-lactokinin [alpha-La (18-19 50-51), kappa-CN (38-39)]. Another value of peptide IC50(EC50) = 2000 uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Peptide found in cod protein hydrolysates: Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf Peptide found in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2882) Inhibitor of nitrogen uptake in yeasts according to the ChEMBL database Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9508) the BRENDA database Inhibitor of Dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database database of bioactive peptides (ID 8936) Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 2 Activity

Activity

IC50
Antihypertensive
1523.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: c1cc(ccc1C[C@@H](C(=O)NCC(=O)O)N)O InChI=1S/C11H14N2O4/c12-9(11(17)13-6-10(15)16)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,17)(H,15,16)/t9-/m0/s1 InChIKey: HPYDSVWYXXKHRD-VIFPVBQESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide known as alpha-lactokinin [alpha-La (18-19 50-51), kappa-CN (38-39)]. Another value of peptide IC50(EC50) = 2000 uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors: Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Peptide found in cod protein hydrolysates: Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf Peptide found in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2882) Inhibitor of nitrogen uptake in yeasts according to the ChEMBL database Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9508) the BRENDA database Inhibitor of Dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database database of bioactive peptides (ID 8936) Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: c1cc(ccc1C[C@@H](C(=O)NCC(=O)O)N)O InChI=1S/C11H14N2O4/c12-9(11(17)13-6-10(15)16)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,17)(H,15,16)/t9-/m0/s1 InChIKey: HPYDSVWYXXKHRD-VIFPVBQESA-N Peptide found also in cod protein hydrolysates: Geirsdóttir M., 2009, Isolation, purification and investigation of peptides from fish proteins with blood pressure decreasing properties. Report from the project funded by the AVS research fund under the Ministry of Fisheries in Iceland (project no. R-047-07). Matís Report 36-09, Matís, Reykjavik, Iceland, http://www.avs.is/media/avs/36-09_skyrsla_einangrun_peptida.pdf Peptide found in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 3553), the ChEMBL database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2882) Inhibitor of nitrogen uptake in yeasts according to the ChEMBL database Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9508) the BRENDA database Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Additional Detail Fields 1 fields
2