TPDB

3D PDB MODEL

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TPDB ID TPDB47572

Peptide_Name

b-lactokinin (fr. of b-lactoglobulin: 142-146)

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

ALPMH

FASTA

>TPDB47572|ACE inhibitors;Antihypertensive|length=5
ALPMH

Formula C25H41N7O6S1

Absent Amino Acids RNDCEQGIKFSTWYV

Common Amino Acids AHLMP

Mass 567.70

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index 0.45

Hydrophobicity 0.540

Aliphatic Index 98.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

1

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C25H41N7O6S1

Mass

567.70

PI

7.85

Net Charge

+0

Boman Index

0.45

Hydrophobicity

0.540

Chemical_Mass

567.7008

Monoisotopic_Mass

567.2830

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 521.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Mullally M., Meisel H., FitzGerald R. J.

Title

Identification of a novel angiotensin I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine b-Lg.FEBS Lett.402,99-102

Year 1997

Literature Source Journal

Other

Number of Residues 5

Additional Info precursor: beta-lactoglobulin fragment (142-148) ACE inhibitor

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antihypertensive

Activity Measurement 521.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Mullally M., Meisel H., FitzGerald R. J.

Title

Identification of a novel angiotensin I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine b-Lg.FEBS Lett.402,99-102

Year 1997

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info precursor: beta-lactoglobulin fragment (142-148) ACE inhibitor

Number_of_Residues

5