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Peptide record

TPDB47569

ACE inhibitor ACE inhibitors Antihypertensive Neuropeptide standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB47569
ACE inhibitor
ACE inhibitors Antihypertensive Neuropeptide
Cardiometabolic peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Neuropeptide) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
LAMA
Physicochemical Analysis
C17H32N4O5S1
RNDCEQGHIKFPSTWYV
A
404.52
6.02
0
0
4
-0
-1.13
2.325
147.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C17H32N4O5S1
404.52
6.02
-0
-1.13
2.325
404.5246
404.2086
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1062.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppälä A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J. Dairy Res., 67, 53-64, 2000
2000
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C17H32N4O5S/c1-9(2)8-12(18)15(23)19-10(3)14(22)21-13(6-7-27-5)16(24)20-11(4)17(25)26/h9-13H,6-8,18H2,1-5H3,(H,19,23)(H,20,24)(H,21,22)(H,25,26)/t10-,11-,12-,13-/m0/s1 InChIKey=NRMOFKYAEXORGF-CYDGBPFRSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
1062.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppälä A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J. Dairy Res., 67, 53-64, 2000
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C17H32N4O5S/c1-9(2)8-12(18)15(23)19-10(3)14(22)21-13(6-7-27-5)16(24)20-11(4)17(25)26/h9-13H,6-8,18H2,1-5H3,(H,19,23)(H,20,24)(H,21,22)(H,25,26)/t10-,11-,12-,13-/m0/s1 InChIKey=NRMOFKYAEXORGF-CYDGBPFRSA-N
Additional Detail Fields 1 fields
4