TPDB

3D PDB MODEL

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TPDB ID TPDB47568

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

VAGTW

FASTA

>TPDB47568|ACE inhibitors;Antihypertensive|length=5
VAGTW

Formula C25H36N6O7

Absent Amino Acids RNDCEQHILKMFPSY

Common Amino Acids AGTWV

Mass 532.60

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -1.80

Hydrophobicity 0.800

Aliphatic Index 78.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 1032.68

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1

Length

5

Formula

C25H36N6O7

Mass

532.60

PI

6.02

Net Charge

-0

Boman Index

-1.80

Hydrophobicity

0.800

Chemical_Mass

532.5879

Monoisotopic_Mass

532.2637

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 534.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)CNC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O InChI=1S/C25H36N6O7/c1-12(2)20(26)23(35)29-13(3)22(34)28-11-19(33)31-21(14(4)32)24(36)30-18(25(37)38)9-15-10-27-17-8-6-5-7-16(15)17/h5-8,10,12-14,18,20-21,27,32H,9,11,26H2,1-4H3,(H,28,34)(H,29,35)(H,30,36)(H,31,33)(H,37,38)/t13-,14+,18-,20-,21-/m0/s1 InChIKey=UDJYYBCFIYCUSO-QAJIRISXSA-N

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 534.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Pihlanto-Leppala A. et al.

Title

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64

Year 2000

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(O)[C@]([H])(NC(=O)CNC(=O)[C@]([H])(C)NC(=O)[C@@]([H])(N)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O InChI=1S/C25H36N6O7/c1-12(2)20(26)23(35)29-13(3)22(34)28-11-19(33)31-21(14(4)32)24(36)30-18(25(37)38)9-15-10-27-17-8-6-5-7-16(15)17/h5-8,10,12-14,18,20-21,27,32H,9,11,26H2,1-4H3,(H,28,34)(H,29,35)(H,30,36)(H,31,33)(H,37,38)/t13-,14+,18-,20-,21-/m0/s1 InChIKey=UDJYYBCFIYCUSO-QAJIRISXSA-N

Number_of_Residues

5