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Peptide record

TPDB47566

ACE inhibitor (fragment of alpha-lactalbumin: 104-108) ACE inhibitors Antihypertensive standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB47566
ACE inhibitor (fragment of alpha-lactalbumin: 104-108)
ACE inhibitors Antihypertensive
Cardiometabolic peptides
FermFooDB Peptipedia AHTPDB AHTpin
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
WLAHK
Physicochemical Analysis
C32H47N9O6
RNDCEQGIMFPSTYV
AHLKW
653.78
10.10
2
0
3
+1
-0.63
-0.480
98.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
841.26
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
5
C32H47N9O6
653.78
10.10
+1
-0.63
-0.480
653.7704
653.3639
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
77.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Pihlanto-Leppala A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J. Dairy Res., 67, 53-64, 2000
2000
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C32H47N9O6/c1-18(2)12-26(41-29(43)23(34)13-20-15-36-24-9-5-4-8-22(20)24)30(44)38-19(3)28(42)40-27(14-21-16-35-17-37-21)31(45)39-25(32(46)47)10-6-7-11-33/h4-5,8-9,15-19,23,25-27,36H,6-7,10-14,33-34H2,1-3H3,(H,35,37)(H,38,44)(H,39,45)(H,40,42)(H,41,43)(H,46,47)/t19-,23-,25-,26-,27-/m0/s1 InChIKey=JOTYPHSZHCKJSP-HUBZGTFKSA-N Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10410) the MBPDB database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10859)
Evidence 2 Activity

Activity

IC50
Antihypertensive
77.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Pihlanto-Leppala A., Koskinen P., Piilola K., Tupasela T., Korhonen H.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J. Dairy Res., 67, 53-64, 2000
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C32H47N9O6/c1-18(2)12-26(41-29(43)23(34)13-20-15-36-24-9-5-4-8-22(20)24)30(44)38-19(3)28(42)40-27(14-21-16-35-17-37-21)31(45)39-25(32(46)47)10-6-7-11-33/h4-5,8-9,15-19,23,25-27,36H,6-7,10-14,33-34H2,1-3H3,(H,35,37)(H,38,44)(H,39,45)(H,40,42)(H,41,43)(H,46,47)/t19-,23-,25-,26-,27-/m0/s1 InChIKey=JOTYPHSZHCKJSP-HUBZGTFKSA-N Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10410) the MBPDB database Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10859)
Additional Detail Fields 1 fields
5