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Peptide record

TPDB47565

ACE inhibitor from Tricholoma giganteum ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47565
ACE inhibitor from Tricholoma giganteum
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
GEP
Physicochemical Analysis
C12H19N3O6
ARNDCQHILKMFSTWYV
EGP
301.30
3.29
0
1
0
-1
2.48
-1.833
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C12H19N3O6
301.30
3.29
-1
2.48
-1.833
301.2950
301.1269
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.31 µM
ACE inhibitor
ah

Source & Reference

NA
Lee D.-H., Kim J.-H., Park J.-S., Choi Y.-J., Lee J.-S.
Isolation and characterization of a novel angiotensin-I converting inhibitory peptides derived from edible mushroom Tricholoma giganteum. Peptides, 2004, 25, 4, 621-627
2004
Journal

Other

3
maximum value of IC 50 = 0,31 mg. After purification of peptide with UF, HPLC and Sephadex G-25 the IC50 was 0,04 mg.
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.31 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Lee D.-H., Kim J.-H., Park J.-S., Choi Y.-J., Lee J.-S.
Isolation and characterization of a novel angiotensin-I converting inhibitory peptides derived from edible mushroom Tricholoma giganteum. Peptides, 2004, 25, 4, 621-627
2004
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
maximum value of IC 50 = 0,31 mg. After purification of peptide with UF, HPLC and Sephadex G-25 the IC50 was 0,04 mg.
Additional Detail Fields 1 fields
3