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Peptide record

TPDB47559

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Neuropeptide iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47559
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides
FermFooDB Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Neuropeptide, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
LQP
Physicochemical Analysis
C16H28N4O5
ARNDCEGHIKMFSTWYV
QLP
356.42
6.02
0
0
1
-0
0.47
-0.433
130.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H28N4O5
356.42
6.02
-0
0.47
-0.433
356.4162
356.2053
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H., Maruyama S.
Structures and activity of angiotensin-converting enzyme inhibitors in an alpha-zein hydrolysate. Agric. Biol. Chem., 55, 1313-1318, 1991
1991
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H28N4O5/c1-9(2)8-10(17)14(22)19-11(5-6-13(18)21)15(23)20-7-3-4-12(20)16(24)25/h9-12H,3-8,17H2,1-2H3,(H2,18,21)(H,19,22)(H,24,25)/t10-,11-,12-/m0/s1 InChIKey=CQGSYZCULZMEDE-SRVKXCTJSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in cheese: Tonouchi H., Suzuki M., Uchida M., Oda M., 2008, Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese. J. Dairy Res., 75, 284-290 found in wheat milling by-products: Nogata Y., Nagamine T., Yanaka M., Ohta H., 2009, Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622 found in amaranth protein hydrolysate: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Miyoshi S., Ishikawa H., Kaneko T., Fukui F., Tanaka H., Maruyama S.
Structures and activity of angiotensin-converting enzyme inhibitors in an alpha-zein hydrolysate. Agric. Biol. Chem., 55, 1313-1318, 1991
1991
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H28N4O5/c1-9(2)8-10(17)14(22)19-11(5-6-13(18)21)15(23)20-7-3-4-12(20)16(24)25/h9-12H,3-8,17H2,1-2H3,(H2,18,21)(H,19,22)(H,24,25)/t10-,11-,12-/m0/s1 InChIKey=CQGSYZCULZMEDE-SRVKXCTJSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in cheese: Tonouchi H., Suzuki M., Uchida M., Oda M., 2008, Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese. J. Dairy Res., 75, 284-290 found in wheat milling by-products: Nogata Y., Nagamine T., Yanaka M., Ohta H., 2009, Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem., 57, 6618-6622 found in amaranth protein hydrolysate: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111
Evidence 3 Activity

Activity

IC50
iDPPIV
1181.10 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51
2014
Journal

Other

3
Also as ACE inhibitor (BIOPEP ID 3542)
Additional Detail Fields 1 fields
3