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Peptide record

TPDB47540

ACE inhibitor from shark meat hydrolysate dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Bitter Umami iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47540
ACE inhibitor from shark meat hydrolysate dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Bitter Umami iDPPIV
Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
EY
Physicochemical Analysis
C14H18N2O6
ARNDCQGHILKMFPSTWV
EY
310.31
3.29
0
1
1
-1
1.08
-2.400
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1490
480.17
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C14H18N2O6
310.31
3.29
-1
1.08
-2.400
310.3018
310.1160
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.68 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu H., He H-L, Chen X-L, Sun C-Y, Zhang Y-Z, Zhou B-C.
Purification and identification of novel angiotensin I-converting enzyme inhibitory peptides from shark meat hydrolysate. Process Biochemistry, 43, 457-461, 2008
2008
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C14H18N2O6/c15-10(5-6-12(18)19)13(20)16-11(14(21)22)7-8-1-3-9(17)4-2-8/h1-4,10-11,17H,5-7,15H2,(H,16,20)(H,18,19)(H,21,22)/t10-,11-/m0/s1 InChIKey: YSWHPLCDIMUKFE-QWRGUYRKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.acBIOPEP-UWM database of bioactive peptides.uk/) ID: M02-001 Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BIOPEP-UWM database of bioactive peptides, the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 273) Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 413)
Evidence 2 Activity

Activity

IC50
Antihypertensive
2.68 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu H., He H-L, Chen X-L, Sun C-Y, Zhang Y-Z, Zhou B-C.
Purification and identification of novel angiotensin I-converting enzyme inhibitory peptides from shark meat hydrolysate. Process Biochemistry, 43, 457-461, 2008
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C14H18N2O6/c15-10(5-6-12(18)19)13(20)16-11(14(21)22)7-8-1-3-9(17)4-2-8/h1-4,10-11,17H,5-7,15H2,(H,16,20)(H,18,19)(H,21,22)/t10-,11-/m0/s1 InChIKey: YSWHPLCDIMUKFE-QWRGUYRKSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.acBIOPEP-UWM database of bioactive peptides.uk/) ID: M02-001 Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BIOPEP-UWM database of bioactive peptides, the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 273) Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 413)
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C14H18N2O6/c15-10(5-6-12(18)19)13(20)16-11(14(21)22)7-8-1-3-9(17)4-2-8/h1-4,10-11,17H,5-7,15H2,(H,16,20)(H,18,19)(H,21,22)/t10-,11-/m0/s1 InChIKey: YSWHPLCDIMUKFE-QWRGUYRKSA-N Inhibitor of Tubulin-tyrosine ligase (EC 6.3.2.25) according to the BIOPEP-UWM database of bioactive peptides, the BRENDA database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 273) Umami peptide according to the BIOPEP database of sensory peptides and amino acids (ID 413)
Additional Detail Fields 1 fields
2