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Peptide record

TPDB47539

ACE inhibitor from shark meat hydrolysate ACE inhibitors Antihypertensive standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB47539
ACE inhibitor from shark meat hydrolysate
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
CF
Physicochemical Analysis
C12H16N2O3S1
ARNDEQGHILKMPSTWYV
CF
268.33
5.33
0
0
1
-0
-1.37
2.650
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C12H16N2O3S1
268.33
5.33
-0
-1.37
2.650
268.3325
268.0878
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.96 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu H., He H-L, Chen X-L, Sun C-Y, Zhang Y-Z, Zhou B-C.
Purification and identification of novel angiotensin I-converting enzyme inhibitory peptides from shark meat hydrolysate. Process Biochemistry, 43, 457-461, 2008
2008
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C12H16N2O3S/c13-9(7-18)11(15)14-10(12(16)17)6-8-4-2-1-3-5-8/h1-5,9-10,18H,6-7,13H2,(H,14,15)(H,16,17)/t9-,10-/m0/s1 InChIKey=XZFYRXDAULDNFX-UWVGGRQHSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.96 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu H., He H-L, Chen X-L, Sun C-Y, Zhang Y-Z, Zhou B-C.
Purification and identification of novel angiotensin I-converting enzyme inhibitory peptides from shark meat hydrolysate. Process Biochemistry, 43, 457-461, 2008
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C12H16N2O3S/c13-9(7-18)11(15)14-10(12(16)17)6-8-4-2-1-3-5-8/h1-5,9-10,18H,6-7,13H2,(H,14,15)(H,16,17)/t9-,10-/m0/s1 InChIKey=XZFYRXDAULDNFX-UWVGGRQHSA-N
Additional Detail Fields 1 fields
2