TPDB

3D PDB MODEL

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TPDB ID TPDB47534

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antihypertensive

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia AHTPDB AHTpin

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.

Sequence

GWAP

FASTA

>TPDB47534|ACE inhibitors;Antihypertensive|length=4
GWAP

Formula C21H27N5O5

Absent Amino Acids RNDCEQHILKMFSTYV

Common Amino Acids AGPW

Mass 429.48

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.56

Hydrophobicity -0.275

Aliphatic Index 25.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 1280.63

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

4

Formula

C21H27N5O5

Mass

429.48

PI

6.02

Net Charge

-0

Boman Index

-1.56

Hydrophobicity

-0.275

Chemical_Mass

429.4685

Monoisotopic_Mass

429.2006

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 3.86 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.

Title

Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245

Year 1994

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C21H27N5O5/c1-12(20(29)26-8-4-7-17(26)21(30)31)24-19(28)16(25-18(27)10-22)9-13-11-23-15-6-3-2-5-14(13)15/h2-3,5-6,11-12,16-17,23H,4,7-10,22H2,1H3,(H,24,28)(H,25,27)(H,30,31)/t12-,16-,17-/m0/s1 InChIKey=FBUMPXILDTWCJW-ZLIFDBKOSA-N EC50 value from article: Murray B. A., FitzGerald R. J., 2007. Curr. Pharm. Des. 13, 8, 773-791.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 3.86 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.

Title

Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245

Year 1994

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)[C@]([H])(CC1=CNC2=C1C=CC=C2)NC(=O)CN)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C21H27N5O5/c1-12(20(29)26-8-4-7-17(26)21(30)31)24-19(28)16(25-18(27)10-22)9-13-11-23-15-6-3-2-5-14(13)15/h2-3,5-6,11-12,16-17,23H,4,7-10,22H2,1H3,(H,24,28)(H,25,27)(H,30,31)/t12-,16-,17-/m0/s1 InChIKey=FBUMPXILDTWCJW-ZLIFDBKOSA-N EC50 value from article: Murray B. A., FitzGerald R. J., 2007. Curr. Pharm. Des. 13, 8, 773-791.

Number_of_Residues

4