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Peptide record

TPDB47533

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47533
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
AKK
Physicochemical Analysis
C15H31N5O4
RNDCEQGHILMFPSTWYV
K
345.44
10.60
2
0
1
+2
1.81
-2.000
33.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C15H31N5O4
345.44
10.60
+2
1.81
-2.000
345.4365
345.2369
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
3.20 µM
ACE inhibitor
ah

Source & Reference

NA
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
1994
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C15H31N5O4/c1-10(18)13(21)19-11(6-2-4-8-16)14(22)20-12(15(23)24)7-3-5-9-17/h10-12H,2-9,16-18H2,1H3,(H,19,21)(H,20,22)(H,23,24)/t10-,11-,12-/m0/s1 InChIKey=VCSABYLVNWQYQE-SRVKXCTJSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
3.20 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C15H31N5O4/c1-10(18)13(21)19-11(6-2-4-8-16)14(22)20-12(15(23)24)7-3-5-9-17/h10-12H,2-9,16-18H2,1H3,(H,19,21)(H,20,22)(H,23,24)/t10-,11-,12-/m0/s1 InChIKey=VCSABYLVNWQYQE-SRVKXCTJSA-N
Additional Detail Fields 1 fields
3