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Peptide record

TPDB47532

ACE inhibitor ACE inhibitors Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB47532
ACE inhibitor
ACE inhibitors Antihypertensive
Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
RFH
Physicochemical Analysis
C21H30N8O4
ANDCEQGILKMPSTWYV
RHF
458.52
11.05
2
0
1
+1
0.64
-1.633
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C21H30N8O4
458.52
11.05
+1
0.64
-1.633
458.5129
458.2384
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
331.00 µM
ACE inhibitor
ah

Source & Reference

NA
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
1994
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC1=CN=CN1)C(O)=O InChI=1S/C21H30N8O4/c22-15(7-4-8-26-21(23)24)18(30)28-16(9-13-5-2-1-3-6-13)19(31)29-17(20(32)33)10-14-11-25-12-27-14/h1-3,5-6,11-12,15-17H,4,7-10,22H2,(H,25,27)(H,28,30)(H,29,31)(H,32,33)(H4,23,24,26)/t15-,16-,17-/m0/s1 InChIKey=FIQKRDXFTANIEJ-ULQDDVLXSA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
331.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Matsufuji H., Matsui T., Seki E., Osajima K., Nakashima M., Osajima Y.
Angiotensin I-converting enzyme inhibitory peptides in an alkaline proteinase hydrolysate derived from sardine muscle. Biosci. Biotech. Biochem., 58, 2244-2245
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC1=CN=CN1)C(O)=O InChI=1S/C21H30N8O4/c22-15(7-4-8-26-21(23)24)18(30)28-16(9-13-5-2-1-3-6-13)19(31)29-17(20(32)33)10-14-11-25-12-27-14/h1-3,5-6,11-12,15-17H,4,7-10,22H2,(H,25,27)(H,28,30)(H,29,31)(H,32,33)(H4,23,24,26)/t15-,16-,17-/m0/s1 InChIKey=FIQKRDXFTANIEJ-ULQDDVLXSA-N
Additional Detail Fields 1 fields
3